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531889 STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem

531889
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Overview

Key Spec Table

CAS #Empirical Formula
1441190-66-4C₂₀H₂₄N₁₀O₁₃P₂ (free acid)

Products

Catalogue NumberPackaging Qty/Pack
5318890001 Glass bottle 500 μg
Description
OverviewA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531889
Brand Family Calbiochem®
Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
References
ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.
Product Information
CAS number1441190-66-4
FormWhite solid
Hill FormulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Hygroscopic Hygroscopic
Quality LevelMQ100
Biological Information
Primary TargetSTING
Primary Target K<sub>i</sub>4 nM, EC₅₀
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5318890001 04055977260014