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559286 RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

The RSK Inhibitor II, also referenced under CAS 501437-28-1, controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870

559286
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
501437-28-1C₁₉H₂₃F₂N₅O₂

Products

Catalogue NumberPackaging Qty/Pack
559286-5MG Glass bottle 5 mg
Description
OverviewThe racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC50 ≤31 nM against RSK1, 2, 3, and 4; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC50 ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated HEK-293 cells and EGF-stimulated Rat-2 cells (IC50 ~1 µM).
Catalogue Number559286
Brand Family Calbiochem®
Synonyms2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
References
ReferencesCarriere, A., et al. 2008. Curr. Biol. 18, 1269
Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.
Product Information
CAS number501437-28-1
FormOff-white solid
Hill FormulaC₁₉H₂₃F₂N₅O₂
Chemical formulaC₁₉H₂₃F₂N₅O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
559286-5MG 04055977192377

Documentation

RSK Inhibitor II - CAS 501437-28-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

RSK Inhibitor II - CAS 501437-28-1 - Calbiochem Certificates of Analysis

TitleLot Number
559286

References

Reference overview
Carriere, A., et al. 2008. Curr. Biol. 18, 1269
Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2012 JSW
Synonyms2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
DescriptionThe racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC50 = 31, 24, 18, and 15 nM against RSK1, 2, 3, and 4, respectively; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC50 ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated human HEK-293 cells and EGF-stimulated rat Rat-2 cells (IC50 ~1 µM). A useful pharmacological reagent for studying RSK-mediated cellular signaling events.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number501437-28-1
Chemical formulaC₁₉H₂₃F₂N₅O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCarriere, A., et al. 2008. Curr. Biol. 18, 1269
Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.