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524736 Phosphodiesterase 4B2, His•Tag®, Human, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDE4B2, cAMP-Specific Phosphodiesterase 4B2

524736
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
524736-10U Plastic ampoule 10 u
Description
OverviewFull-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His•Tag® sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.
Catalogue Number524736
Brand Family Calbiochem®
SynonymsPDE4B2, cAMP-Specific Phosphodiesterase 4B2
Application Data
Phosphodiesterase 4B2 was treated with increasing concentrations of the inhibitor, rolipram, and the activity assayed. the IC50 for this inhibition is 1.77 µM.
References
ReferencesGibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
Smith, P.G., et al. 2005 Blood 105, 308.
Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.
Product Information
Activity≥ 0.25 units/µl
Unit of DefinitionOne unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
FormLiquid
FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
Quality LevelMQ100
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
524736-10U 04055977197709

Documentation

Phosphodiesterase 4B2, His•Tag®, Human, Recombinant, S. frugiperda SDS

Title

Safety Data Sheet (SDS) 

Phosphodiesterase 4B2, His•Tag®, Human, Recombinant, S. frugiperda Certificates of Analysis

TitleLot Number
524736

References

Reference overview
Gibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
Smith, P.G., et al. 2005 Blood 105, 308.
Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-March-2009 JSW
SynonymsPDE4B2, cAMP-Specific Phosphodiesterase 4B2
Application Data
Phosphodiesterase 4B2 was treated with increasing concentrations of the inhibitor, rolipram, and the activity assayed. the IC50 for this inhibition is 1.77 µM.
DescriptionFull-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His•Tag® sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.
FormLiquid
FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
Activity≥ 0.25 units/µl
Unit definitionOne unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesGibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39.
Smith, P.G., et al. 2005 Blood 105, 308.
Baroja, M.L., et al. 1999. J. Immunol. 162, 2016.