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14-910M PI3K-C2γ Protein, 250 µg

N-terminal GST-tagged recombinant human PI3K-C2γ, amino acids 468–1203, for use in Kinase Assays.

PI3K-C2γ Protein, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-910M
250 µg  Also available in 10 μg size (cat#14-910) and in bulk (cat# 14-910-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-910M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPI3K-C2γ Protein, 250 µg
OverviewN-terminal GST-tagged recombinant human PI3K-C2γ amino acids 468–1203
References
Product Information
Presentation0.54mg/ml of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Quality LevelMQ100
Applications
ApplicationN-terminal GST-tagged recombinant human PI3K-C2γ, amino acids 468–1203, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.
Gene Symbol
  • PI3-kinase
  • PIK3
  • PI3K
  • PTDINS-3-kinase
  • PI3K C2g
  • PI3-Kinase Class II
  • PIK3C2G
Protein TargetPI3K-C2γ
Purification MethodGlutathione agarose affinity chromatography
Target Sub-FamilyPI3K/PI4K
UniProt Number
UniProt SummaryFUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2
CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein
TISSUE SPECIFICITY: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
SIMILARITY: Belongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain. Contains 1 PX (phox homology) domain.
Molecular Weight112kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated in the PIProfiler.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-910) and in bulk (cat# 14-910-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-910M 04053252410130

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-910 PI3K-C2γ Protein, 10 µg

Product Families

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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases