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528111 PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

528111
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Overview

Key Spec Table

CAS #Empirical Formula
1188890-32-5C₁₆H₁₅N₃O₂S • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
528111-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
Catalogue Number528111
Brand Family Calbiochem®
Synonyms3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
References
ReferencesHayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.
Product Information
CAS number1188890-32-5
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₅N₃O₂S • 2HCl
Chemical formulaC₁₆H₁₅N₃O₂S • 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPI 3-Kα
Primary Target IC<sub>50</sub>2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
528111-5MG 04055977270525