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491207 Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 491207) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: retrovirus RNA-dependent DNA polymerases
491207
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1476-53-5C₃₁H₃₅N₂O₁₁ · Na

Products

Catalogue NumberPackaging Qty/Pack
491207-10GM Glass bottle 10 gm
Description
OverviewDNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
Catalogue Number491207
Brand Family Calbiochem®
References
ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Product Information
CAS number1476-53-5
ATP CompetitiveN
FormWhite to yellow solid
Hill FormulaC₃₁H₃₅N₂O₁₁ · Na
Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetretrovirus RNA-dependent DNA polymerases
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRD5425000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
491207-10GM 07790788050818

Documentation

Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Certificates of Analysis

TitleLot Number
491207

References

Reference overview
Marcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-May-2018 JSW
DescriptionA DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
FormWhite to yellow solid
CAS number1476-53-5
RTECSRD5425000
Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
Purity≥90% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
Toxicity Harmful
Merck USA index14, 6722
ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.