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482210 Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide

482210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1021926-22-6C₂₄H₃₂N₂O₄S

Products

Catalogue NumberPackaging Qty/Pack
482210-5MG 5 mg
Description
OverviewA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
Catalogue Number482210
Brand Family Calbiochem®
SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
References
ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.
Product Information
CAS number1021926-22-6
FormOff-white solid
Hill FormulaC₂₄H₃₂N₂O₄S
Chemical formulaC₂₄H₃₂N₂O₄S
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
482210-5MG 04055977183504

Documentation

Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nimesulide Analog, Compound 76 - CAS 1021926-22-6 - Calbiochem Certificates of Analysis

TitleLot Number
482210

References

Reference overview
Chen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-(3-(2,5-dimethylbenzyloxy)-4-(N-methylmethylsulfonamido)phenyl)cyclohexanecarboxamide
DescriptionA cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
FormOff-white solid
CAS number1021926-22-6
Chemical formulaC₂₄H₃₂N₂O₄S
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesChen, B., et al. 2009. Biochem. Pharmacol. 77, 1787.
Su, B., et al. 2008. J. Comb. Chem. 10, 475.