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476300 Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

476300
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Overview

Key Spec Table

CAS #Empirical Formula
35891-70-4C₂₁H₃₉NO₆

Products

Catalogue NumberPackaging Qty/Pack
476300-5MG Plastic ampoule 5 mg
Description
OverviewA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
Catalogue Number476300
Brand Family Calbiochem®
SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
References
ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
Fujita, T., et al. 1994. J. Antibiot. 47, 208.
Product Information
CAS number35891-70-4
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₁H₃₉NO₆
Chemical formulaC₂₁H₃₉NO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetSerine palmitoyltransferase
Primary Target K<sub>i</sub>280 pM against serine palmitoyltransferase
Purity≥95% by TLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSJX3890000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
476300-5MG 04055977183801