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FCMAB214P Sigma-AldrichMilli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2

Milli-Mark Anti-CD117 Antibody, c-kit-PE, clone 104D2 detects level of CD117 & has been published & validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA

Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P10721

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Overview

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC	M	Phycoerythrin	Monoclonal Antibody

Description
Catalogue Number	FCMAB214P
Trade Name	Milli-Mark
Description	Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2
Alternate Names	Mast/stem cell growth factor receptor SCFR Tyrosine-protein kinase Kit Proto-oncogene c-Kit
Background Information	CD117 is a 145 kDa transmembrane protein which belongs to the class III receptor tyrosine kinase family. The extracellular region consists of five immunoglobulin-like domains where the second and third loops are thought to be involved in ligand binding (Ashman, 1997; Bühring, 1995). CD117 has been shown to be a marker for tissue mast cells, hematopoietic stem cells, and progenitor cells in normal human bone marrow. The majority of CD117-positive marrow cells (50-70%) co-express CD34 and comprise progenitor cells and their precursors of all hematopoietic lineages. Apart from mast cells, CD117 is essentially absent from mature hematopoietic cells. Although CD117 is primarily a marker for non-lymphoid progenitor cells in the hematopoietic cells/tissues, including melanocytes, embryonic brain, and the reproductive system (Ashman, 1997). Anti-CD117, 104D2, was included in the Sixth International Workshop and Conference on Human Leucocyte differentiation Antigens, and studies by different laboratories confirmed its reactivity with CD117 (Ashman, 1997).

References

Product Information
Format	Phycoerythrin
Control	TF-1 cells
Presentation	Purified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality Level	MQ100

Applications
Application	Milli-Mark Anti-CD117 Antibody, c-kit-PE, clone 104D2 detects level of CD117 & has been published & validated for use in FC.
Key Applications	Flow Cytometry

Biological Information
Immunogen	MOLM-1 megakaryocytic cell line.
Clone	104D2
Host	Mouse
Specificity	Antibody recognizes Human CD117 antigen.
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000213
Entrez Gene Summary	This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method	Protein A Purfied
UniProt Number	P10721
UniProt Summary	This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (PI3K). Defects in KIT are a cause of piebaldism. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes
Molecular Weight	145 kDa (Ashman, 1997; Buhring, 1995)

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by flow cytometry using TF-1 cells
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Packaging Information
Material Size	100 tests

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
FCMAB214P	04053252480232

Documentation

Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2 SDS

Title
Safety Data Sheet (SDS)

Milli-Mark™ Anti-CD117 Antibody, c-kit-PE, clone 104D2 Certificates of Analysis

Title	Lot Number
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1985163	1985163
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1987083	1987083
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 1995601	1995601
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 2005384	2005384
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 2059940	2059940
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - NRG1779490	NRG1779490
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 - 3288479	3288479
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 -2505433	2505433
Milli-Mark Anti-CD117, c-kit-PE, clone 104D2 -2506577	2506577
Milli-Mark™ Anti-CD117, c-kit-PE, clone 104D2 - 2390560	2390560

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Categories

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