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23-032M MDM2/CK1δ Protein, active, 250 µg

Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Key Applications: Enzyme Assays
23-032M
250 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman E3
Description
Catalogue Number23-032M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMDM2/CK1δ Protein, active, 250 µg
OverviewFlocked swab:
Spray-on Nylon is the secret to flocked swab technology. The short, perpendicular fiber strands produced by the spray on method, creates an absorbent, thin-layer open structure that enhances both sample collection and release through the natural capillary movement of liquid along the fibers. Elution of the liquid and solid specimen sample is rapid and automatic because they are maintained close to the surface of the swab between the nylon strands, spontaneously draining when placed in liquid or onto solid media. Swab shafts are scored at a specific break-point for easy transfer of the tip into transportation media.

Universal Transport Medium (UTM):
UTM is provided with labeled capture-cap vials designed for transport of the clinical sample. The capture cap is designed to secure the shaft of the swab sample to the cap, eliminating the use of forceps to remove the swab in the laboratory.
Alternate Names
  • Double minute 2 protein
  • p53-binding protein Mdm2
  • Hdm2
Background InformationMDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications
  • Enzyme Assays
Biological Information
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose followed by gel filtration.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
23-032M 04053252294488

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
23-032 MDM2/CK1δ Protein, active, 10 µg

Product Families

Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
Learn More >>

Categories

Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases