688002 Sigma-AldrichInSolution™ Y-27632 in DMSO - Calbiochem
InSolution™ Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK).
More>> InSolution™ Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Less<<InSolution™ Y-27632 in DMSO - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
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Overview
Key Spec Table
| Empirical Formula |
|---|
| C₁₄H₂₁N₃O•2HCl•H₂O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 688002-1MG | Glass bottle | 1 mg |
| Description | |
|---|---|
| Overview | A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available. |
| Catalogue Number | 688002 |
| Brand Family | Calbiochem® |
| Synonyms | (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO. |
| Hill Formula | C₁₄H₂₁N₃O•2HCl•H₂O |
| Chemical formula | C₁₄H₂₁N₃O•2HCl•H₂O |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Safety Information | |
|---|---|
| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 688002-1MG | 04055977225464 |