565794 Sigma-AldrichInSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
More>> The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 797035-11-1 | C₃₁H₃₈N₄O₅S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 565794-500UG | Glass bottle | 500 μg |
| Description | |
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| Overview | A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available. |
| Catalogue Number | 565794 |
| Brand Family | Calbiochem® |
| Synonyms | N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide |
| References | |
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| References | Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |
| Product Information | |
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| CAS number | 797035-11-1 |
| Form | Liquid |
| Formulation | A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO. |
| Hill Formula | C₃₁H₃₈N₄O₅S |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | β-Secretase |
| Primary Target IC<sub>50</sub> | 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 565794-500UG | 04055977191905 |
Documentation
InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem SDS
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InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 565794 |
References
| Reference overview |
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| Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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