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371962 InSolution™ H-89, Dihydrochloride - Calbiochem

371962
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Overview

Key Spec Table

Empirical Formula
C₂₀H₂₀BrN₃O₂S

Products

Catalogue NumberPackaging Qty/Pack
371962-1MG Plastic ampoule 1 mg
Description
Catalogue Number371962
Brand Family Calbiochem®
SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
References
ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
Davies, S.P. et al. 2000. Biochem. J. 351, 95.
de Rooij, J., et al. 1998. Nature. 396, 474.
Kawasaki, H., et al. 1998. Science. 282, 2275.
Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
Hill FormulaC₂₀H₂₀BrN₃O₂S
Chemical formulaC₂₀H₂₀BrN₃O₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
Biological Information
Primary TargetPKA
Primary Target K<sub>i</sub>48 nM against protein kinase A
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
371962-1MG 04055977213515