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208750 InSolution™ ALLN - CAS 110044-82-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V

Primary Target: calpain 1
208750
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

Products

Catalogue NumberPackaging Qty/Pack
208750-5MG Glass bottle 5 mg
Description
Catalogue Number208750
Brand Family Calbiochem®
SynonymsCalpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
References
ReferencesMilligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
Product Information
CAS number110044-82-1
ATP CompetitiveN
FormClear colorless solution
FormulationA 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
Hill FormulaC₂₀H₃₇N₃O₄
Chemical formulaC₂₀H₃₇N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcalpain 1
Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Flammable
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
208750-5MG 04055977202847

Documentation

InSolution™ ALLN - CAS 110044-82-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ ALLN - CAS 110044-82-1 - Calbiochem Certificates of Analysis

TitleLot Number
208750

References

Reference overview
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-May-2008 RFH
    SynonymsCalpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
    DescriptionA 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex.
    FormClear colorless solution
    FormulationA 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number110044-82-1
    Chemical formulaC₂₀H₃₇N₃O₄
    Structure formulaStructure formula
    Purity≥95% by HPLC
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Flammable
    ReferencesMilligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
    Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
    Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
    Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
    Citation
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•