Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

12-533 GSM (GSK3 substrate peptide)

12-533
1 mg  
Purchase on Sigma-Aldrich

Overview

Description
Catalogue Number12-533
Brand Family Upstate
Trade Name
  • Upstate
DescriptionGSM (GSK3 substrate peptide)
OverviewSynthetic peptide (RRRPASVPPSPSLS RHS(pS)HQRR) based on muscle glycogen synthase 1, where (pS) corresponds to phosphorylated serine.
Product Information
Presentation1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Application NotesKinase Assay: Substrate for GSK3α, active (Catalog # 14-492), GSK3β, active (Catalog # 14-306), GSK3β, active, rat (Catalog # 14-538).
Biological Information
Entrez Gene Number
Entrez Gene SummaryGlycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
Gene Symbol
  • GSK3A
  • DKFZp686D0638
Protein TargetGSK3
Target Sub-FamilyCMGC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).
SIZE: 483 amino acids; 50981 Da
SUBUNIT: Monomer (By similarity).
SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
Molecular WeightMolecular weight: 2673 Daltons.
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for GSK3β (Catalog # 14-306).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C
Packaging Information
Material Size1 mg
Global Trade Item Number
Catalogue Number GTIN
12-533 04053252743931