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361548 GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor

Primary Target: GSK-3β
361548
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
99-73-0C₈H₆Br₂O

Products

Catalogue NumberPackaging Qty/Pack
361548-5MG Plastic ampoule 5 mg
Description
OverviewA phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
Catalogue Number361548
Brand Family Calbiochem®
Synonymsα-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
References
ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
Product Information
CAS number99-73-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₆Br₂O
Chemical formulaC₈H₆Br₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β
Primary Target IC<sub>50</sub>0.5 µM against GSK-3β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAM6950000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361548-5MG 04055977214048

Documentation

GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem Certificates of Analysis

TitleLot Number
361548

References

Reference overview
Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-July-2008 RFH
Synonymsα-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
DescriptionA phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC50 = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number99-73-0
RTECSAM6950000
Chemical formulaC₈H₆Br₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.