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324759 Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

Primary Target: Neutrophil elastase
324759
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
127373-66-4C₂₀H₂₂N₂O₇S

Products

Catalogue NumberPackaging Qty/Pack
324759-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
Catalogue Number324759
Brand Family Calbiochem®
SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
References
ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
Product Information
CAS number127373-66-4
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₀H₂₂N₂O₇S
Chemical formulaC₂₀H₂₂N₂O₇S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNeutrophil elastase
Primary Target IC<sub>50</sub>19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324759-1MG 04055977216080

Documentation

Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem Certificates of Analysis

TitleLot Number
324759

References

Reference overview
Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
DescriptionA cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC50 = 5.6 µM) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number127373-66-4
Chemical formulaC₂₀H₂₂N₂O₇S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.