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138001 D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem

The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO

138001
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
61977-29-5C₇H₄ClNO₂

Products

Catalogue NumberPackaging Qty/Pack
138001-50MG Glass bottle 50 mg
Description
OverviewA cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo.
Catalogue Number138001
Brand Family Calbiochem®
Synonyms6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
References
ReferencesGong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.
Product Information
CAS number61977-29-5
FormOff-white powder
Hill FormulaC₇H₄ClNO₂
Chemical formulaC₇H₄ClNO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
138001-50MG 04055977222319

Documentation

D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem Certificates of Analysis

TitleLot Number
138001

References

Reference overview
Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-October-2011 RFH
Synonyms6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
DescriptionA cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number61977-29-5
Chemical formulaC₇H₄ClNO₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml). It is recommended to prepare a stock solution for 6 month use each time and store the unreconstituted material in solid form, protected from moisture and preferably under inert gas, for best long-term stability during storage.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesGong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.