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219364 Cathepsin B, Human Liver

219364
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Overview

Products

Catalogue NumberPackaging Qty/Pack
219364-5U Plastic ampoule 5 u
Description
OverviewNative cathepsin B from human liver, purified by affinity chromatography. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities. Cathepsin B is shown to facilitate tumor invasion by dissolving extracellular barriers.
Catalogue Number219364
Brand Family Calbiochem®
References
ReferencesKostoulas, G., et al. 1999. FEBS Lett. 455, 286.
Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.
Keppler, D., et al. 1994. Biochim. Biophys. Acta. 1226, 117.
Musil, D., et al. 1991. EMBO J. 10, 2321.
Sloane B.F. 1990. Semin. Cancer Biol. 1, 137.
Product Information
CAS number9047-22-7
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-βNA per min at 40°C, pH 6.0 in the presence of DTT.
EC number3.4.22.1
FormLiquid
FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
Quality LevelMQ100
Biological Information
Purity>95% by SDS-PAGE
SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥50 U/mg protein
Concentration Label Please refer to vial label for lot-specific concentration
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Global Trade Item Number
Catalogue Number GTIN
219364-5U 04055977202212