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203732 Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem

Lipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Brevetoxin B, GbTx-2

Primary Target: Neurotoxin that binds to Na+ channels on nerves and muscles.
203732
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
79580-28-2C₅₀H₇₀O₁₄

Products

Catalogue NumberPackaging Qty/Pack
203732-100UG Glass bottle 100 μg
Description
OverviewLipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel.
Catalogue Number203732
Brand Family Calbiochem®
SynonymsBrevetoxin B, GbTx-2
References
ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, G. 1989. FASEB J. 3, 1807.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Nakanishi, K. 1985. Toxicon 23, 473.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
Product Information
CAS number79580-28-2
ATP CompetitiveN
FormTan to white solid
Hill FormulaC₅₀H₇₀O₁₄
Chemical formulaC₅₀H₇₀O₁₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNeurotoxin that binds to Na+ channels on nerves and muscles.
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXW5886000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


From Catalog:
Solubitlity- removed acetone, EtOAc
End use certificateY
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203732-100UG 04055977203851

Documentation

Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem Certificates of Analysis

TitleLot Number
203732

References

Reference overview
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, G. 1989. FASEB J. 3, 1807.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Nakanishi, K. 1985. Toxicon 23, 473.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2008 RFH
SynonymsBrevetoxin B, GbTx-2
DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
FormTan to white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number79580-28-2
RTECSXW5886000
Chemical formulaC₅₀H₇₀O₁₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityEthyl acetate, Methanol or H₂O
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


From Catalog:
Solubitlity- removed acetone, EtOAc
Toxicity Highly Toxic
ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, G. 1989. FASEB J. 3, 1807.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Nakanishi, K. 1985. Toxicon 23, 473.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.