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203895 BTS - CAS 1576-37-0 - Calbiochem

A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

BTS - CAS 1576-37-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Benzyl-p-toluenesulphonamide

Primary Target: Ca2+-stimulated myosin S1 ATPase
203895
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1576-37-0C₁₄H₁₅NO₂S

Products

Catalogue NumberPackaging Qty/Pack
203895-5MG Plastic ampoule 5 mg
Description
OverviewA potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
Catalogue Number203895
Brand Family Calbiochem®
SynonymsN-Benzyl-p-toluenesulphonamide
References
ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
Product Information
CAS number1576-37-0
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₄H₁₅NO₂S
Chemical formulaC₁₄H₁₅NO₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCa2+-stimulated myosin S1 ATPase
Primary Target IC<sub>50</sub>~5 µM against Ca2+-stimulated myosin S1 ATPase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXT5490000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203895-5MG 04055977219920

Documentation

BTS - CAS 1576-37-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BTS - CAS 1576-37-0 - Calbiochem Certificates of Analysis

TitleLot Number
203895

References

Reference overview
Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-May-2008 RFH
SynonymsN-Benzyl-p-toluenesulphonamide
DescriptionAn aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50 < 2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1576-37-0
RTECSXT5490000
Chemical formulaC₁₄H₁₅NO₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.