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GF166 BMP-2 Protein, Human Recombinant

The Human Bone morphogenetic protein 2 (or BMP-2 protein) is a member of the BMP protein subgroup of the TGFβ superfamily.

BMP-2 Protein, Human Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P12643
GF166
10 µg  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

SourcePurity
E. coli.Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue NumberGF166
DescriptionBMP-2 Protein, Human Recombinant
Alternate Names
  • Bone Morphogenetic Protein 2
  • BMP2
  • BMP-2A
Background InformationBone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGFβ superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
Product Information
PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
ApplicationThe Human Bone morphogenetic protein 2 (or BMP-2 protein) is a member of the BMP protein subgroup of the TGFβ superfamily.
Biological Information
PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
SourceE. coli.
Cross ReactivityMouse, Rat, Rabbit, Cow, Dog, Monkey
UniProt Number
Product Usage Statements
Quality AssuranceBioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size10 µg
Global Trade Item Number
Catalogue Number GTIN
GF166 04053252691232