Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB1580-I Anti-Mu Opioid Receptor Antibody

Detect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).

Anti-Mu Opioid Receptor Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: OPRM1, MOR1 UniProt Number: P35372
AB1580-I
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB1580-I
ReplacesAB1580
DescriptionAnti-Mu Opioid Receptor Antibody
Alternate Names
  • Mu-type opioid receptor
  • M-OR-1
  • MOR-1
  • Mu opiate receptor
  • Mu opioid receptor
  • MOP
  • hMOP
  • Anti-Opioid Receptor μ
Background InformationMu Opioid Receptor (MOP), also called Mu-type opioid receptor (MOR-1), is a receptor for natural and synthetic opioids such as beta-endorphin, endomorphin, morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. MOP functions as a class A G-protein coupled receptor (GPCR), but its down-regulation pathways vary with the agonist and may or may not be independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling, as opposed to synthetic ligands, like morphine, that trigger only low desensitization and endocytosis. Hetero-oligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. MOP is expressed in the brain and is involved in neurogenesis. MOP is the main physiological target for most clinically important opioid analgesics.
References
Product Information
FormatAffinity Purified
HS Code3002 15 90
Control
  • SH-SY5Y cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:1,000-4,000 dilution from a representative lot detected Mu Opioid Receptor in human cerebellum, mouse hippocampus, mouse midbrain, and rat midbrain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human Mu Opioid Receptor.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the C-terminus of Mu Opioid Receptor. This antibody will recognize isoform 1 (45 kDa), isform 10 (55 kDa), isoform 12 (34 kDa), and isoform 13 (36 kDa).
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteDemonstrated to react with Human and Mouse. Predicted to react with Rat, Porcine, and Bovine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • OPRM1
  • MOR1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~70 kDa observed. The calculated molecular weight is 45 kDa, however Opioid Receptor mu has been shown as a ~70-90 kDa band in western blots (Ferrer-Alcon, M., et al. (2004). Molecular Brain Research. 121(1-2):114-122).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Mu Opioid Receptor in 10 µg of SH-SY5Y cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB1580-I 04053252906664

Documentation

Anti-Mu Opioid Receptor Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Mu Opioid Receptor Antibody Certificates of Analysis

TitleLot Number
Anti-Mu Opioid Receptor - 3209145 3209145
Anti-Mu Opioid Receptor - 3323042 3323042
Anti-Mu Opioid Receptor - 3609983 3609983
Anti-Mu Opioid Receptor - 3944869 3944869
Anti-Mu Opioid Receptor - 4186080 4186080
Anti-Mu Opioid Receptor - Q2187981 Q2187981
Anti-Mu Opioid Receptor -2555310 2555310
Anti-Mu Opioid Receptor -2641704 2641704
Anti-Mu Opioid Receptor -2687788 2687788
Anti-Mu Opioid Receptor -2736410 2736410
Show more