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06-1095 Anti-Interferon Beta Antibody

Detect Interferon Beta using this Anti-Interferon Beta Antibody validated for use in WB, NEUT, IH(P).

Anti-Interferon Beta Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IFNB1, IFB, IFF, IFNB UniProt Number: P01574
06-1095
200 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, BWB, NEUT, IH(P)RbSerumPolyclonal Antibody
Description
Catalogue Number06-1095
DescriptionAnti-Interferon Beta Antibody
Alternate Names
  • interferon, beta 1, fibroblast
  • interferon beta
  • Fibroblast interferon
  • IFN-beta
Background InformationInterferon beta is a type I IFN regulatory cytokine belonging to a conserved family of secreted proteins that have demonstrated growth-inhibitory, immunomodulatory and antiviral properties. Due to these properties, the type I IFNs have been of considerable interest and use in various clinical functions. Studies have shown Interferon beta to be a potent immunomodulator and tumor growth suppressor through the down-regulation of MGMT. Also, there has been great interest in this cytokine as a possible approach to gene therapy for patients infected with AIDS.
References
Product Information
FormatSerum
Control
  • Recombinant human Interferon Beta
PresentationRabbit polyclonal containing serum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Interferon Beta using this Anti-Interferon Beta Antibody validated for use in WB, NEUT, IH(P).
Key Applications
  • Western Blotting
  • Neutralizing
  • Immunohistochemistry (Paraffin)
Application NotesNeutralizing Activity Assay Analysis: One unit of neutralization activity is defined as the amount of antibody serum required to inactivate one unit of Interferon Beta activity in a viral resistant assay, i.e., VSV virus and MDBK cell line (Rubinstein S. Familletti, P.C. and Pestka S. Journal of Virology, 1981, 37:755-758). Neutralization activity is measured by the inhibition of VSV infection of MDBK cells in the presence and absence of the neutralization antibody (ability of the antibody to block interferon's protection of MDBK from VSV infection). This antibody has a neutralization activity of 6.0 x 10^5 units/mL. (Note: Interferon Beta response is species specific)

Immunohistochemistry (Paraffin) Analysis: A 1:500 dilution from a previous lot detected Interferon Beta in benign prostate tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the internal domain of human Interferon beta.
EpitopeInternal Domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes Interferon beta.

Bioactivity
1.2 x 10^5 Units @ 6.0 x 10^5 Neutralization Units/mL
Species Reactivity
  • Human
  • Bovine
Species Reactivity NoteDemonstrated to react with human and bovine.
Rhesus monkey and chimpanzee (91% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • IFNB1
  • IFB
  • IFF
  • IFNB
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Has antiviral, antibacterial and anticancer activities.

SUBUNIT STRUCTURE: Monomer.

SUBCELLULAR LOCATION: Secreted.

PHARMACEUTICAL USE: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

SEQUENCE SIMILARITIES: Belongs to the alpha/beta interferon family.
Molecular Weight~ 18 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in recombinant human Interferon beta.

Western Blot Analysis: A 1:500 dilution of this antibody detected 10 µg of recombinant human Interferon Beta.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
06-1095 04053252517464

Documentation

Anti-Interferon Beta Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Interferon Beta Antibody Certificates of Analysis

TitleLot Number
Anti-Interferon Beta 2480843
Anti-Interferon Beta - 2179371 2179371
Anti-Interferon Beta - 2291716 2291716
Anti-Interferon Beta - 3515618 3515618
Anti-Interferon Beta - NG1809751 NG1809751
Anti-Interferon Beta - NG1904279 NG1904279
Anti-Interferon Beta - NRG1742831 NRG1742831
Anti-Interferon Beta -2638034 2638034
Anti-Interferon Beta -2712480 2712480
Anti-Interferon Beta Polyclonal Antibody 2981042
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