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ABC844 Anti-IEX1 Antibody

Anti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence.

Anti-IEX1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: IER3, DIF2, IEX1, PRG1 UniProt Number: P46695
ABC844
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC844
DescriptionAnti-IEX1 Antibody
Alternate Names
  • Radiation-inducible immediate-early gene IEX-1
  • Differentiation-dependent gene 2 protein
  • Protein DIF-2
  • Immediate early protein GLY96
  • Immediate early response 3 protein
  • PACAP-responsive gene 1 protein
  • Protein PRG1
  • IEX1
Background InformationRadiation-inducible immediate-early gene IEX-1, also known as Differentiation-dependent gene 2 protein (DIF-2) or PACAP-responsive gene 1 protein (Protein PRG1), and encoded by the gene name IER3 or DIF2 or IEX1 or PRG1, is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-α. IEX1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. IEX1 plays an important role in the regulation of cellular growth, cell death and oncogenesis and is precisely regulated by multiple transcription factors such as p53, NF-κB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX1 in cells under a variety of stress conditions. IEX1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX1 expression is associated with decreases in both apoptosis and cell cycle progression.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected IEX1 in human liver tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IEX1 in human brain cells.
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human IEX1.
EpitopeCenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • IER3
  • DIF2
  • IEX1
  • PRG1
Purification MethodAffinity
UniProt Number
Molecular Weight~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 4 μg/mL of this antibody detected IEX1 in human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC844 04053252944109