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190080 AY 9944 - CAS 366-93-8 - Calbiochem

190080
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Overview

Key Spec Table

CAS #Empirical Formula
366-93-8C₂₂H₂₈Cl₂N₂ • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
190080-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
Catalogue Number190080
Brand Family Calbiochem®
Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
References
ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem. 98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
Product Information
CAS number366-93-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₈Cl₂N₂ • 2HCl
Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Target7-dehydrocholesterol reductase (δ7-sterol reductase)
Primary Target IC<sub>50</sub>13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSGU7025000
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
190080-5MG 04055977221336