Clarisolve® Depth Filters

For Efficient Primary Clarification of Pretreated Feed Streams

The Clarisolve^® depth filter is a novel clarification tool with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams. Offering improved volumetric capacity and reduced turbidity over current available depth filters, the clarification step of pre-treated feeds can be processed in a significantly reduced footprint without the need for a secondary stage of clarification.

Benefits

• Provides fastest and most efficient way to clarify high-density pre-treated feed streams
• Enables processing of pretreated feeds in a significantly reduced footprint with reduced flushing requirements
• Eliminates the need for centrifugation and enables implementation of a fully single-use process train
• Fully scalable from lab to pilot to process scale

Need a flocculation polymer?

• pDADMAC solution 10% flocculation polymer is an effective pre-treatment that can be used in combination with the Clarisolve^® depth filters
  
  Learn more

Read more about Clarisolve^® Depth Filters

• Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes
  – Pharmaceutical Bioprocessing, 2015, 3(2), 115-125
• Selection of Clarification Methods for Improved Downstream Performance and Economics
  – BioProcessing Journal, Fall 2015, Vol. 14/Issue 3
• Complete Clarification Solution for Processing High Density Cell Culture Harvests
  – Separation and Purification Technology, Feb. 2015, Vol. 141
• pDADMAC Flocculant Reagent for Use with Clarisolve^® Depth Filters
  – BioProcess International Industry Yearbook August 2014-2015
• Evolving Clarification Strategies to Meet New Challenges
  – BioProcess International, October 2014
• Development of a Novel and Efficient Cell Culture Flocculation Process Using a Stimulus Responsive Polymer to Streamline Antibody Purification Processes
  – Biotechnology & Bioengineering, Nov. 2013, Vol. 110/Issue 11
• Process Cost and Facility Considerations in the Selection of Primary Cell Culture Clarification Technology
  – Biotechnology Progress, June 2013, Vol. 29/Issue 5

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