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506170 p53-Snail binding Inhibitor, GN25 - Calbiochem

The p53-Snail binding Inhibitor, GN25 controls the biological activity of p53-Snail. This small molecule/inhibitor is primarily used for Neuroscience applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: GN25

506170
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₅H₁₄O₆S

Products

Número de referenciaEmbalaje Cant./Env.
506170-25MG Frasco de vidrio 25 mg
Description
OverviewA cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
Catalogue Number506170
Brand Family Calbiochem®
SynonymsGN25
References
ReferencesLee, S., et al. 2010. Oncogene 29, 4576.
Product Information
FormOrange powder
Hill FormulaC₁₅H₁₄O₆S
Chemical formulaC₁₅H₁₄O₆S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
506170-25MG 04055977272369

Documentation

p53-Snail binding Inhibitor, GN25 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

p53-Snail binding Inhibitor, GN25 - Calbiochem Certificados de análisis

CargoNúmero de lote
506170

Referencias bibliográficas

Visión general referencias
Lee, S., et al. 2010. Oncogene 29, 4576.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
SynonymsGN25
DescriptionA cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
FormOrange powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₄O₆S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLee, S., et al. 2010. Oncogene 29, 4576.