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506106 p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem

506106
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Descripción

Tabla espec. clave

CAS #Empirical Formula
42521-82-4C₂₀H₁₄O₂S₂

Products

Número de referenciaEmbalaje Cant./Env.
506106-25MG Ampolla de plást. 25 mg
506106-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC50 = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.
Catalogue Number506106
Brand Family Calbiochem®
Synonyms2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III
References
ReferencesDeacon, S.W., et al. 2008. Chem. Biol. 15, 322.
Product Information
CAS number42521-82-4
FormYellow solid
Hill FormulaC₂₀H₁₄O₂S₂
Chemical formulaC₂₀H₁₄O₂S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥97% by HPLC
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Número de referencia GTIN
506106-25MG 04055977199413
506106-5MG 07790788050863