324517 Sigma-AldricheIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
More>> eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. Less<<Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
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Descripción
Tabla espec. clave
| CAS # | Empirical Formula |
|---|---|
| 315706-13-9 | C₁₈H₁₂Cl₂N₄O₄S |
Products
| Número de referencia | Embalaje | Cant./Env. | |
|---|---|---|---|
| 324517-10MG | Ampolla de plást. | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519). |
| Catalogue Number | 324517 |
| Brand Family | Calbiochem® |
| Synonyms | 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I |
| References | |
|---|---|
| References | Moerke, N. J., et al. 2007. Cell 128, 257. |
| Product Information | |
|---|---|
| CAS number | 315706-13-9 |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₂Cl₂N₄O₄S |
| Chemical formula | C₁₈H₁₂Cl₂N₄O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. |
| Biological Information | |
|---|---|
| Purity | ≥98% by HPLC (sum of two isomers) |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Número de referencia | GTIN |
| 324517-10MG | 04055977197327 |