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23-056 XIAP, active

XIAP, active: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Enzyme Assays Entrez Gene Number: NM_001167
23-056
10 µg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number23-056
Brand Family Upstate
Trade Name
  • Upstate
DescriptionXIAP, active
Alternate Names
  • Baculoviral IAP repeat-containing protein 4 (BIRC4)
  • IAP-like protein
  • Inhibitor of apoptosis protein 3 (API3)
Background InformationX-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.
References
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose, followed by gel filtration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
23-056 04053252919039

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Alternative Packsize

Número de referencia Descripción
23-056M XIAP, active

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Categorías

Life Science Research > Proteins and Enzymes > Other Proteins