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676492 VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

VEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: MAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I

Primary Target: VEGF receptor tyrosine kinase
676492
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
163655-37-6C₂₁H₁₈N₂O

Products

Número de referenciaEmbalaje Cant./Env.
676492-10MG Ampolla de plást. 10 mg
Description
OverviewA cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
Catalogue Number676492
Brand Family Calbiochem®
SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
References
ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
Product Information
CAS number163655-37-6
ATP CompetitiveY
DeclarationNot available for sale in Germany.
FormRed solid
Hill FormulaC₂₁H₁₈N₂O
Chemical formulaC₂₁H₁₈N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationVEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.
Biological Information
Primary TargetVEGF receptor tyrosine kinase
Primary Target IC<sub>50</sub>At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
676492-10MG 04055977183689

Documentation

VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem Certificados de análisis

CargoNúmero de lote
676492

Referencias bibliográficas

Visión general referencias
Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
DescriptionA cell-permeable, 3-substituted, indolin-2-one compound that acts as a reversible and ATP-competitive inhibitor of VEGF receptor tyrosine kinase. At low concentrations (5 µM), reported to specifically block VEGF-C and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. Reported to partially block VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential inhibition may be useful for controlling lymphangiogenesis-dependent tumor metastasis and could, therefore, be of clinical significance for cancer therapy studies.
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number163655-37-6
Chemical formulaC₂₁H₁₈N₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530