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614853 Topoisomerase II Inhibitor, BNS-22 - Calbiochem

The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: BNS-22

614853
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₄H₂₅NO₅

Products

Número de referenciaEmbalaje Cant./Env.
614853-10MG Frasco de vidrio 10 mg
Description
OverviewA potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
Catalogue Number614853
Brand Family Calbiochem®
SynonymsBNS-22
References
ReferencesKawatani, M., et al. 2011. Chem Biol. 18, 743.
Product Information
FormWhite solid
Hill FormulaC₂₄H₂₅NO₅
Chemical formulaC₂₄H₂₅NO₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
614853-10MG 04055977263206

Documentation

Topoisomerase II Inhibitor, BNS-22 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Topoisomerase II Inhibitor, BNS-22 - Calbiochem Certificados de análisis

CargoNúmero de lote
614853

Referencias bibliográficas

Visión general referencias
Kawatani, M., et al. 2011. Chem Biol. 18, 743.

Folleto

Cargo
New Products: Volume 3, 2012
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-April-2012 JSW
SynonymsBNS-22
DescriptionA potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₅NO₅
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (25 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKawatani, M., et al. 2011. Chem Biol. 18, 743.