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23-059 TRAF6, active

TRAF6, active: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Enzyme Assays
23-059
10 µg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman E3
Description
Catalogue Number23-059
Brand Family Upstate
Trade Name
  • Upstate
DescriptionTRAF6, active
Alternate Names
  • TNF receptor-associated factor 6
  • Interleukin-1 signal transducer
  • RING finger protein 85
Background InformationTRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signalling pathways including those emanating from the tumour-necrosis-factor receptor (TNFR) and interleukin-1/Toll-like receptors (IL-1R/TLR). TRAF6 also transduces signals from receptors such as CD40 and RANK and may be essential for the formation of functional osteoclasts. Studies indicate that amplification of the TRAF6 locus is a somatic and frequent event in several human cancer types and is a commonly amplified oncogene bridging RAS and NF-κB in lung cancer. Inhibition of TRAF6 in lung cancer cells has been shown to suppress NF-κB activation, anchorage-independent growth and tumour formation.
References
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
23-059 04053252959530

Productos y aplicaciones relacionados

Alternative Packsize

Número de referencia Descripción
23-059M TRAF6, active

Familias de productos

Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
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Categorías

Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases