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616394 TPEN - CAS 16858-02-9 - Calbiochem

TPEN - CAS 16858-02-9 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine

616394
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
16858-02-9C₂₆H₂₈N₆

Products

Número de referenciaEmbalaje Cant./Env.
616394-100MG Ampolla de plást. 100 mg
Description
OverviewLipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826).
Catalogue Number616394
Brand Family Calbiochem®
SynonymsN,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine
References
ReferencesFonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.
Product Information
CAS number16858-02-9
FormTan solid
Hill FormulaC₂₆H₂₈N₆
Chemical formulaC₂₆H₂₈N₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
616394-100MG 04055977185621

Documentation

TPEN - CAS 16858-02-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

TPEN - CAS 16858-02-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
616394

Referencias bibliográficas

Visión general referencias
Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2010 RFH
SynonymsN,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine
DescriptionLipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer's disease brain tissue.
FormTan solid
CAS number16858-02-9
Chemical formulaC₂₆H₂₈N₆
Structure formulaStructure formula
Purity≥97% by titration
SolubilityDMSO, Ethanol (10 mg/ml), or PBS (25 µM in 100 mM PBS, pH 7.0)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.