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654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl

Primary Target: TNF-α
654256
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1049741-03-8C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O

Products

Número de referenciaEmbalaje Cant./Env.
654256-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
Catalogue Number654256
Brand Family Calbiochem®
SynonymsTumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
References
ReferencesHe, M.M., et al. 2005. Science 310, 1022.
Product Information
CAS number1049741-03-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α
Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
654256-5MG 04055977184631

Documentation

TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
654256

Referencias bibliográficas

Visión general referencias
He, M.M., et al. 2005. Science 310, 1022.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsTumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
DescriptionA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1049741-03-8
Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHe, M.M., et al. 2005. Science 310, 1022.