616452 MilliporeTGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
More>> TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation). Less<<Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Productos recomendados
Descripción
| Replacement Information |
|---|
Tabla espec. clave
| CAS # | Empirical Formula |
|---|---|
| 446859-33-2 | C₁₇H₁₃N₅ |
Products
| Número de referencia | Embalaje | Cant./Env. | |
|---|---|---|---|
| 616452-2MG | Frasco de vidrio | 2 mg |
| Description | |
|---|---|
| Overview | A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158). |
| Catalogue Number | 616452 |
| Brand Family | Calbiochem® |
| Synonyms | ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
| References | |
|---|---|
| References | Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494. Ichida, J. K., et al. 2009. 5, 491. |
| Product Information | |
|---|---|
| CAS number | 446859-33-2 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₃N₅ |
| Chemical formula | C₁₇H₁₃N₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | ALKS binding |
| Primary Target IC<sub>50</sub> | 23 nM |
| Secondary target | ALK 5 auto phosphorylation (IC₅₀ = 4 nM) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Número de referencia | GTIN |
| 616452-2MG | 04055977185829 |
Documentation
TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Ficha datos de seguridad (MSDS)
| Título |
|---|
TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Certificados de análisis
| Cargo | Número de lote |
|---|---|
| 616452 |
Referencias bibliográficas
| Visión general referencias |
|---|
| Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494. Ichida, J. K., et al. 2009. 5, 491. |
Ficha técnica
| Cargo |
|---|
| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Citas
| Título | |
|---|---|
|
| Ficha técnica | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|