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567021 Simvastatin, Sodium Salt - Calbiochem

Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.

Simvastatin, Sodium Salt - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: L-Type Calcium Channel Blocker VI

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
567021
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₅H₃₉O₆ • Na

Products

Número de referenciaEmbalaje Cant./Env.
567021-50MG Frasco de vidrio 50 mg
567021-5MG Ampolla de plást. 5 mg
Description
OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
Catalogue Number567021
Brand Family Calbiochem®
SynonymsL-Type Calcium Channel Blocker VI
References
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Product Information
ATP CompetitiveN
FormBeige solid
Hill FormulaC₂₅H₃₉O₆ • Na
Chemical formulaC₂₅H₃₉O₆ • Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
567021-50MG 04055977267112
567021-5MG 07790788051587

Documentation

Simvastatin, Sodium Salt - Calbiochem Certificados de análisis

CargoNúmero de lote
567021

Referencias bibliográficas

Visión general referencias
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-October-2015 JSW
SynonymsL-Type Calcium Channel Blocker VI
DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₃₉O₆ • Na
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.