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420294 STAT5 Inhibitor II, IQDMA - Calbiochem

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

STAT5 Inhibitor II, IQDMA - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

420294
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₉H₂₀N₄

Products

Número de referenciaEmbalaje Cant./Env.
420294-10MG 10 mg
Description
OverviewA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
Catalogue Number420294
Brand Family Calbiochem®
SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
References
ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.
Product Information
FormWhite to beige solid
Hill FormulaC₁₉H₂₀N₄
Chemical formulaC₁₉H₂₀N₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
420294-10MG 04055977210897

Documentation

STAT5 Inhibitor II, IQDMA - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

STAT5 Inhibitor II, IQDMA - Calbiochem Certificados de análisis

CargoNúmero de lote
420294

Referencias bibliográficas

Visión general referencias
Su, J.C., et al. 2009, Life Sci. 85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.

Folleto

Cargo
Pathways and Biomarkers of JAK/STAT Signaling

Licencias necesarias e Información técnica

Cargo
JAK/STAT Signaling Research Focus
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-May-2020 JSW
SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
DescriptionA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
FormWhite to beige solid
Chemical formulaC₁₉H₂₀N₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.