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567300 SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem

Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Proadifen

Primary Target: nNOS
567300
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
62-68-0C₂₃H₃₁NO₂ . HCl

Products

Número de referenciaEmbalaje Cant./Env.
567300-1GM Ampolla de plást. 1 gm
Description
OverviewCell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.
Catalogue Number567300
Brand Family Calbiochem®
SynonymsProadifen
References
ReferencesHecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.
Product Information
CAS number62-68-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₃₁NO₂ . HCl
Chemical formulaC₂₃H₃₁NO₂ . HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetnNOS
Primary Target IC<sub>50</sub>90 µM against neuronal nitric oxide synthase
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYV7175000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
567300-1GM 04055977267181

Documentation

SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
567300

Referencias bibliográficas

Visión general referencias
Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.

Folleto

Cargo
Pathways and Biomarkers of Oxidative Stress
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-September-2008 RFH
SynonymsProadifen
DescriptionCell permeable. Blocks glibenclamide-sensitive K+ channels (IC50 = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.
FormWhite solid
CAS number62-68-0
RTECSYV7175000
Chemical formulaC₂₃H₃₁NO₂ . HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (20 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful
ReferencesHecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.