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566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem

SIRT1 Inhibitor IV, (S)-35, CAS 848193-72-6, is a cell-permeable, entiomerically pure compound that displays similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide

566325
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
848193-72-6C₁₄H₁₅ClN₂O

Products

Número de referenciaEmbalaje Cant./Env.
566325-500UG Ampolla de plást. 500 μg
Description
OverviewA cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 min in mice in vivo.
Catalogue Number566325
Brand Family Calbiochem®
Synonyms(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
Application Data
References
ReferencesNapper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
Product Information
CAS number848193-72-6
FormOff-white solid
Hill FormulaC₁₄H₁₅ClN₂O
Chemical formulaC₁₄H₁₅ClN₂O
Quality LevelMQ100
Applications
ApplicationSIRT1 Inhibitor IV, (S)-35, CAS 848193-72-6, is a cell-permeable, entiomerically pure compound that displays similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322).
Biological Information
Purity≥96% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
566325-500UG 04055977191424

Documentation

SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem Certificados de análisis

CargoNúmero de lote
566325

Referencias bibliográficas

Visión general referencias
Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.

Ficha técnica

Cargo
SIRTainty™ Class III HDAC Assay
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2009 RFH
Synonyms(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
Application Data
DescriptionA cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number848193-72-6
Chemical formulaC₁₄H₁₅ClN₂O
Purity≥96% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesNapper, A.D., et al. 2005. J. Med. Chem. 48, 8045.