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559393 SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride

Primary Target: p38β
559393
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
350228-36-3C₂₀H₁₄FN₃O · HCl

Products

Número de referenciaEmbalaje Cant./Env.
559393-1MG Ampolla de plást. 1 mg
Description
OverviewA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
Catalogue Number559393
Brand Family Calbiochem®
Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
References
Product Information
CAS number350228-36-3
ATP CompetitiveY
FormAmber solid
Hill FormulaC₂₀H₁₄FN₃O · HCl
Chemical formulaC₂₀H₁₄FN₃O · HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp38β
Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
Primary Target K<sub>i</sub>16 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
559393-1MG 04055977192544

Documentation

SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
559393

Citas

Título
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-April-2011 RFH
    Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
    DescriptionA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
    FormAmber solid
    CAS number350228-36-3
    Chemical formulaC₂₀H₁₄FN₃O · HCl
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO or slightly soluble in H₂O (0.5 mg/ml)
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
    Toxicity Standard Handling
    Citation
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    		•