559303 Sigma-AldrichSANT-1 - CAS 304909-07-7 - Calbiochem
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
More>> A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors. Less<<SANT-1 - CAS 304909-07-7 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: Shh Signaling Antagonist V
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Descripción
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Tabla espec. clave
| CAS # | Empirical Formula |
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| 304909-07-7 | C₂₃H₂₇N₅ |
Products
| Número de referencia | Embalaje | Cant./Env. | |
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| 559303-5MG | Ampolla de plást. | 5 mg |
| Description | |
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| Overview | A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay). |
| Catalogue Number | 559303 |
| Brand Family | Calbiochem® |
| Synonyms | Shh Signaling Antagonist V |
| References | |
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| References | Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
| Product Information | |
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| CAS number | 304909-07-7 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₃H₂₇N₅ |
| Chemical formula | C₂₃H₂₇N₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Número de referencia | GTIN |
| 559303-5MG | 04055977192414 |
Documentation
SANT-1 - CAS 304909-07-7 - Calbiochem Ficha datos de seguridad (MSDS)
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SANT-1 - CAS 304909-07-7 - Calbiochem Certificados de análisis
| Cargo | Número de lote |
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| 559303 |
Referencias bibliográficas
| Visión general referencias |
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| Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |