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HTS217RTA Ready-to-Assay™ GPR39 Orphan Receptor Frozen Cells

HTS217RTA
1 kit  
Purchase on Sigma-Aldrich

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This product requires a User Agreement (Label License). Please see product datasheet for further information

Tabla espec. clave

SpeciesHost CellsProtein Target
Human HEK293GPR39
Description
Catalogue NumberHTS217RTA
Trade Name
  • Ready-to-Assay
DescriptionReady-to-Assay™ GPR39 Orphan Receptor Frozen Cells
Background InformationMillipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

GPR39 is a 7TM protein related to the G protein-coupled receptors for the gastrointestinal peptides ghrelin and motilin. Although GPR39 has been reported to be a receptor for the peptide obestatin, GPR39 has been more thoroughly characterized as a receptor for Zn2+, as well as Cu2+ and Ni2+ (Holst et al., 2007; Yasuda et al., 2007). Studies on GPR39-null mice implicate GPR39 in the control of insulin secretion, thereby indicating its potential as a target for treatment of diabetes (Holst et al., 2009; Tremblay et al., 2009). Millipore’s cloned human GPR39-expressing cell line is made in the HEK293 host, which supports high levels of recombinant GPR39 expression on the cell surface for functional detection via the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at GPR39.
References
Product Information
Components
  • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
  • Fifty (50) mL of Media Component.
Detection methodFluorescent
Quality LevelMQ100
Applications
ApplicationHuman GPR39 GPCR frozen cells for Calcium Flux FLIPR Assays.
Key Applications
  • Calcium Flux Assays
Biological Information
Entrez Gene Number
GPCR ClassA
Host CellsHEK293
Protein TargetGPR39
Target Sub-FamilyOrphan
Cell Line Type
  • GPCR Cell Lines
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size1 kit
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
HTS217RTA 04053252422225

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Categorías

Life Science Research > Cell Culture and Systems > Cell Lines > GPCR Frozen Cells
Life Science Research > Drug Discovery and Development > GPCR Cell Lines & Assays > GPCR Frozen Cells