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14-612M RIPK2 Protein, active, 250 µg

Active, human RIPK2, amino acids 1-299, for use in Kinase Assays.

14-612M
250 µg  Also available in 10 μg size (cat#14-612) and in bulk (cat#14-612-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-612M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionRIPK2 Protein, active, 250 µg
Overviewhuman RIPK2, amino acids 1-299
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, human RIPK2, amino acids 1-299, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceN-terminal His6-tagged, recombinant, human RIPK2 expressed by baculovirus in Sf21 insect cells
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Gene Symbol
  • RIPK2
  • RIP2
  • GIG30
  • RICK
  • CARDIAK
  • CARD3
  • CCK
  • RIP-2
Protein TargetRIPK2
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTKL
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O43353 # Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
SIZE: 540 amino acids; 61195 Da
SUBUNIT: Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: O43353 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 CARD domain. & Contains 1 protein kinase domain.
Molecular Weight37.8kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of MBP
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-612) and in bulk (cat#14-612-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-612M 04053252924293

Documentation

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Alternative Packsize

Número de referencia Descripción
14-612 RIPK2 Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases