504297 Sigma-AldrichRIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206 nM in Jurkat cells).
More>> RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206 nM in Jurkat cells). Less<<Sinónimos: 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methyl-2,4-imidazolidinedione, 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione, 7-Cl-O-MH-Trp, Nec-1s, Nec-1 stable, RIPK1 Inhibitor II, Receptor-Interacting Protein 1 Inhibitor II, Necrosis Inhibitor IV, 7N-1
Productos recomendados
-
19-143 Sigma-Aldrich PD 98059 -
1003182500 Supelco Ácido clorhídrico 30% -
NA81-50UG Sigma-Aldrich Anti-5-Methylcytosine Mouse mAb (162 33 D3) -
1505470001 Supelco Hibar®RT 250-4,6 LiChrospher®RP-18, 5µm -
12-549 Sigma-Aldrich STK Substrate 2 -
AC111S Sigma-Aldrich Sheep Anti-Mouse IgG Antibody, Species absorbed, Cy5 Conjugate -
1091081000 Supelco Potasio hidróxido en solución -
809711 Sigma-Aldrich Metilo acetato -
NAC-A100/12 Millipore NovAseptic Connector, According to PED, Tube Standard ASTM A270 -
CWSC02SB1 Millipore Bevigard-M de 20 pulg. (50 cm); 0,5 µm, código 0
Descripción
Tabla espec. clave
CAS # | Empirical Formula |
---|---|
852391-15-2 | C₁₃H₁₂ClN₃O₂ |
Products
Número de referencia | Embalaje | Cant./Env. | |
---|---|---|---|
5042970001 | Frasco de vidrio | 10 mg |
Description | |
---|---|
Overview | A cell-permeable 7-chloroindolylmethyl-hydantoin that exhibits highly RIP1-selective inhibitory activity among >400 human kinases and is superior to its structural analog Necrostatin-1 (Cat. No. 480065) in blocking RIP1-dependent necroptosis due to improved potency (EC50 = 206 nM vs. 494 nM with Nec-1 for protecting FADD-deficient Jurkat from 30 h 10 ng/mL TNF-α-induced death), selectivity, metabolic stability, as well as reduced in vitro and in vivo toxicity. Reported to be blood-brain barrier permeable in mice and be efficacious in reducing brain infarct size when applied via intracerebroventricular injections in a murine MCAO model in vivo (8 nmol/2 µL/mouse). |
Catalogue Number | 504297 |
Brand Family | Calbiochem® |
Synonyms | 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methyl-2,4-imidazolidinedione, 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione, 7-Cl-O-MH-Trp, Nec-1s, Nec-1 stable, RIPK1 Inhibitor II, Receptor-Interacting Protein 1 Inhibitor II, Necrosis Inhibitor IV, 7N-1 |
Product Information | |
---|---|
CAS number | 852391-15-2 |
Form | Off-white to pale yellow solid |
Hill Formula | C₁₃H₁₂ClN₃O₂ |
Chemical formula | C₁₃H₁₂ClN₃O₂ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
---|---|
Application | RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206 nM in Jurkat cells). |
Biological Information | |
---|---|
Primary Target | RIP1 |
Purity | ≥95% by HPLC |
Physicochemical Information | |
---|---|
Cell permeable | Y |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Número de referencia | GTIN |
5042970001 | 04055977263916 |