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504297 RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem

504297
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Descripción

Tabla espec. clave

CAS #Empirical Formula
852391-15-2C₁₃H₁₂ClN₃O₂

Products

Número de referenciaEmbalaje Cant./Env.
5042970001 Frasco de vidrio 10 mg
Description
OverviewA cell-permeable 7-chloroindolylmethyl-hydantoin that exhibits highly RIP1-selective inhibitory activity among >400 human kinases and is superior to its structural analog Necrostatin-1 (Cat. No. 480065) in blocking RIP1-dependent necroptosis due to improved potency (EC50 = 206 nM vs. 494 nM with Nec-1 for protecting FADD-deficient Jurkat from 30 h 10 ng/mL TNF-α-induced death), selectivity, metabolic stability, as well as reduced in vitro and in vivo toxicity. Reported to be blood-brain barrier permeable in mice and be efficacious in reducing brain infarct size when applied via intracerebroventricular injections in a murine MCAO model in vivo (8 nmol/2 µL/mouse).
Catalogue Number504297
Brand Family Calbiochem®
Synonyms5-((7-Chloro-1H-indol-3-yl)methyl)-3-methyl-2,4-imidazolidinedione, 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione, 7-Cl-O-MH-Trp, Nec-1s, Nec-1 stable, RIPK1 Inhibitor II, Receptor-Interacting Protein 1 Inhibitor II, Necrosis Inhibitor IV, 7N-1
References
ReferencesOfengeim, D., et al. 2015. Cell Reports 10, In press.
Muller, A.J., et al. 2005. Nat. Med. 11, 312.
Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
Degterev, A., et al. 2013. Cell Death Differ. 20, 366.
Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.
Product Information
CAS number852391-15-2
FormOff-white to pale yellow solid
Hill FormulaC₁₃H₁₂ClN₃O₂
Chemical formulaC₁₃H₁₂ClN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206 nM in Jurkat cells).
Biological Information
Primary TargetRIP1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Número de referencia GTIN
5042970001 04055977263916