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540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).

Purmorphamine - CAS 483367-10-8 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

Primary Target: Activation of the Hedgehog signaling pathway
540220
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
483367-10-8C₃₁H₃₂N₆O₂

Products

Número de referenciaEmbalaje Cant./Env.
540220-20MG Frasco de vidrio 20 mg
540220-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number540220
Brand Family Calbiochem®
Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
References
ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
Product Information
CAS number483367-10-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₃₁H₃₂N₆O₂
Chemical formulaC₃₁H₃₂N₆O₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetActivation of the Hedgehog signaling pathway
Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-68

Harmful if swallowed.
Possible risks of irreversible effects.
S PhraseS: 22-36/37

Do not breathe dust.
Wear suitable protective clothing and gloves.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
540220-20MG 04055977268737
540220-5MG 07790788051389

Documentation

Purmorphamine - CAS 483367-10-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
540220

Referencias bibliográficas

Visión general referencias
Wu, X., et al. 2004. Chem. Biol. 11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-November-2014 JSW
Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
DescriptionA cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50 = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number483367-10-8
Chemical formulaC₃₁H₃₂N₆O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.