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528281 Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem

The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine

528281
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
775294-82-1C₂₄H₂₇ClN₂O₄

Products

Número de referenciaEmbalaje Cant./Env.
528281-10MG 10 mg
Description
OverviewA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
Catalogue Number528281
Brand Family Calbiochem®
SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
References
ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.
Product Information
CAS number775294-82-1
FormBeige solid
Hill FormulaC₂₄H₂₇ClN₂O₄
Chemical formulaC₂₄H₂₇ClN₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
528281-10MG 04055977196566

Documentation

Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
528281

Referencias bibliográficas

Visión general referencias
Keppner, S., et al. 2009. ChemMedChem. 4, 1806.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
DescriptionA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number775294-82-1
Chemical formulaC₂₄H₂₇ClN₂O₄
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.