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527948 Sigma-AldrichPiceatannol - CAS 10083-24-6 - Calbiochem

A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM).

Piceatannol - CAS 10083-24-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Ficha datos de seguridad (MSDS)
Certificado de análisis (CoA)
Referencias bibliográficas
Data Sheet

Sinónimos: trans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene

Primary Target: Activity of rat liver protein kinase A catalytic subunit

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Descripción

Replacement Information

Tabla espec. clave

CAS #	Empirical Formula
10083-24-6	C₁₄H₁₂O₄

Products

Número de referencia	Embalaje	Cant./Env.
527948-1MG	Ampolla de plást.	1 mg	Añadir a favoritos Añadir a favoritos Añadido a Mis favoritos

Description
Overview	A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca²⁺-dependent protein kinase (CDPK) (IC₅₀ = 19 µM), and p72^syk (IC₅₀ = 10 µM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number	527948
Brand Family	Calbiochem®
Synonyms	trans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene

References
References	Howitz, K.T., et al. 2003. Nature 425, 191. Wang, B.H., et al. 1998. Planta Med. 64, 195. Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668. Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697. Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950. Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.

Product Information
CAS number	10083-24-6
ATP Competitive	Y
Form	Off-white crystalline solid
Hill Formula	C₁₄H₁₂O₄
Chemical formula	C₁₄H₁₂O₄
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Activity of rat liver protein kinase A catalytic subunit
Primary Target IC<sub>50</sub>	3 µM, 8 µM, and 12 µM against the activity of rat liver protein kinase A catalytic subunit, PKC, and MLCK, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Número de referencia	GTIN
527948-1MG	07790788051143

Documentation

Piceatannol - CAS 10083-24-6 - Calbiochem Ficha datos de seguridad (MSDS)

Título
Ficha técnica de seguridad del material (MSDS)

Piceatannol - CAS 10083-24-6 - Calbiochem Certificados de análisis

Cargo	Número de lote
527948	Introduzca el número de lote

Referencias bibliográficas

Visión general referencias
Howitz, K.T., et al. 2003. Nature 425, 191. Wang, B.H., et al. 1998. Planta Med. 64, 195. Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668. Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697. Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950. Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.

Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-March-2010
Synonyms	trans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene
Description	A cell-permeable, substrate competitive, and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca²⁺-dependent protein kinase (CDPK) (IC₅₀ = 19 µM), and p72^syk (IC₅₀ = 10 µM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Form	Off-white crystalline solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	10083-24-6
Chemical formula	C₁₄H₁₂O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity	Standard Handling
References	Howitz, K.T., et al. 2003. Nature 425, 191. Wang, B.H., et al. 1998. Planta Med. 64, 195. Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668. Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697. Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950. Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.

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