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52332 Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Benzylsulfonyl Fluoride, PMSF

Primary Target: serine proteases
52332
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
329-98-6C₇H₇FO₂S

Products

Número de referenciaEmbalaje Cant./Env.
52332-1GM Tambor de alum 1 gm
52332-25GM Caja de cartón 25 gm
52332-5GM Frasco de vidrio 5 gm
Description
OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Catalogue Number52332
Brand Family Calbiochem®
SynonymsBenzylsulfonyl Fluoride, PMSF
References
ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
Product Information
CAS number329-98-6
ATP CompetitiveN
FormWhite to off-white crystalline solid
Hill FormulaC₇H₇FO₂S
Chemical formulaC₇H₇FO₂S
Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Targetserine proteases
Purity≥99% by GC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXT8040000
Safety Information
R PhraseR: 34

Causes burns.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
52332-1GM 07790788051044
52332-25GM 04055977271508
52332-5GM 04055977271515

Documentation

Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem Certificados de análisis

CargoNúmero de lote
52332

Referencias bibliográficas

Visión general referencias
Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure

Citas

Título
  • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-August-2008 RFH
    SynonymsBenzylsulfonyl Fluoride, PMSF
    DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
    FormWhite to off-white crystalline solid
    CAS number329-98-6
    RTECSXT8040000
    Chemical formulaC₇H₇FO₂S
    Structure formulaStructure formula
    Purity≥99% by GC
    SolubilityEthanol, isopropanol, or methanol
    Storage Protect from moisture
    +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
    Toxicity Corrosive
    ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
    Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
    Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
    Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
    Citation
  • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
    		•